Normal levels were achieved in most patients. ResultsĪfter supplementation, 25(OH)D 3 levels increased significantly. 25(OH)D 3 levels measured on Beckman Coulter DXI 800 by chemiluminescence method. Concentrations of nitric oxide (NO), vascular endothelial growth factor A (VEGF-A), leptin, trimethylamine N-oxide (TMAO) and soluble suppression of tumorigenicity 2 (sST2) were measured in baseline samples using ELISA (BioTek EPOCH). For three months, the subjects supplemented with cholecalciferol at a dose of 2000 IU/day.

The study enrolled 33 obese patients with insufficient 25(OH)D 3 levels. Our study investigates the effect of cholecalciferol supplementation in obese patients on selected biomarkers associated with cardiovascular diseases (CVDs). While the effects of a deficiency on the skeletal or immune system are known, the effects on the cardiovascular system are not yet clear. Obese patients are most at risk of having serum 25-hydroxyvitamin D 3 (25(OH)D 3) levels that are too low due to the accumulation of vitamin D in adipose tissue. Please click here for detailed T&C.Vitamin D deficiency is one of the most common health issues in developed countries. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation.

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